Medications

Erectile Dysfunction And Drug Interactions: My Canadian Pharmacy Technicians Warn Against

In one person in ten, at most, ED drugs can cause headaches, facial redness, stomach burns, myalgia and back pain. However, these are completely innocuous medicines. In one case, they can be dangerous if administered without medical supervision: if the patient is cardiopathic and takes nitrates. The combination of these treatments can cause a drop in blood pressure, up to collapse. Nitrates are contained in heart disease treatments such as nitroglycerin and drugs used in the treatment of angina pectoris. Sildenafil is also contraindicated for retinitis pigmentosa patients. In this article, we will give the floor to My Canadian Pharmacy technicians who explain the nature of PDE5 inhibitors and drug combinations that they should not become part of, whatever you do.

Viagra, Cialis, Levitra: best ED drugs of choice for My Canadian Pharmacy

Sildenafil was discovered during clinical trials carried out in the development of a drug to treat angina pectoris. From this molecule were born the two follow-ups, tadalafil and vardenafil. All three drugs work by imitating the natural body reaction: they are not aphrodisiac and help man reach erection only in the presence of a sexual stimulus. The efficacy of sildenafil starts about 30-40 minutes after intake and lasts up to 10 hours. There are three tablets on the market with different dosages, 25 mg, 50 mg and 100 mg. The positive effects of this treatment were found in 78% of patients with ED.

Vardenafil is a pill with doses of 5, 10 and 20 mg. Usually you take at least 30 minutes before having a sexual relationship and its effect may last as per sildenafil up to a maximum of 10 hours. 80% of patients demonstrated improvements in erectile capacity after taking this drug. Tadalafil is a pill of yellow color and has the shape of an almond. On the market there are 10 or 20 mg tablets. It should be taken between half an hour and an hour before sexual intercourse and the duration of its effects is 36 hours. This means for the patient the possibility of greater freedom of action. No need for any programming, it does not create any performance anxiety. Of this molecule there is also a reduced dose of 5 mg, to be taken daily, as a cure for impotence, eliminating the need to plan sexual intercourse.

Main drug interactions

‘Poppers’: The term “popper” is meant to indicate a set of particular chemicals, which are used for recreational purposes. More in detail, these substances belong to the class of alkyl nitrite (or alkyl nitrite – https://en.wikipedia.org/wiki/Alkyl_nitrites). The latter, from a chemical point of view, are nothing but aliphatic, cyclic or heterocyclic esters of nitrous acid. Generally, when talking about popper, we refer to amylitrile nitrite products, isopropyl nitrite, butyl nitrite or isobutyl nitrite, but sometimes other compounds such as, for example, cyclohexyl nitrite. However, in most cases, when talking about popper, a mixture containing amyl nitrate and butyl nitrate is to be indicated. Alkyl nitrites are liquid compounds, generally yellow and highly flammable; Moreover, they are all characterized by high volatility.

It is no coincidence that the route of administration through which these substances are absorbed is just that of the inhaled type. The popper, in fact, are commonly “sniffed” directly from the glass bottle inside which they are contained. The smell of popper is quite characteristic and is often referred to as sweet and nauseating, or as pungent but still pleasing. In fact, some of these substances were also sold in the form of liquid incenses or home perfumes (in particular, butyl nitrite).

Macrolide antibiotics: Macrolides are a class of antibiotics of natural origin. The parent of this class is erythromycin, obtained from cultures of Streptomyces erythraeus. Macrolides – or macrolide antibiotics – have their name for the large nickel ring (from a chemical point of view, is a cyclic ester) that characterizes their chemical structure. Generally, this tetronic ring is made up of 14, 15 or 16 terms and binds two or more sugars. Macrolides constitute the prescription drugs for treating certain types of infection in patients who have had allergic reactions to penicillins because they have a similar spectrum of action. Macrolids possess bacteriostatic activity (ie they inhibit bacterial growth), but at high concentrations they can also become bactericidal (ie they are capable of killing bacterial cells).

Among the drugs belonging to this class of antibiotics, we mention erythromycin, clarithromycin, azithromycin and spiramycin. As mentioned above, macrolides possess a spectrum of action that may be comparable to that of mid-spectrum penicillins.

Macrolides are primarily administered orally, sometimes in the form of gastroresistant pharmaceutical formulations, since they are unstable in the stomach acid environment. They are used primarily for the treatment of non-serious systemic infections of the respiratory system, the mammary glands, the liver, the kidneys and the prostate.

More specifically, macrolides can be used to treat:

Infections of high and low respiratory tracts and soft tissues caused by Gram-positive bacteria such as Streptococcus pyogenes and Streptococcus pneumoniae;
Upper and lower respiratory tract infections and middle ear otitis caused by Haemophilus influenzae (usually in combination with a sulphamide);
Pneumonia for mycoplasmas;
Mycobacterium avium complex (MAC) infections in AIDS patients (usually rifabutin, an antibiotic belonging to the rifamycin class);
Morale of the Legionnaire;
Prophylaxis of bacterial endocarditis caused by Streptococcus viridans;
Gonorrhea;
Pelvic Inflammatory Disease (PID) caused by mixed infections by bactericidal cell wall bodies such as Chlamydia trachomatis.
In addition, clarithromycin may be used in a mixture of drugs used to treat gastric ulcer caused by Helicobacter pylori infections.

Macrolides exemplify their antibiotic action by interfering with the protein synthesis of bacteria. The synthesis of proteins in bacterial cells is due to specific organelles called ribosomes.

Ribosomes consist of ribosomal RNA (rRNA) and proteins, which are associated with two subunits:

30S subunit, consisting of 21 proteins and one RNA molecule (16S);
50S subunit, consisting of 34 proteins and two RNA molecules (23S and 5S).

The task of these organs is to bind and translate the messenger RNA (mRNA) from the cell nucleus and to synthesize the proteins for which it encodes. The macrolides are able to bind to the ribosomal subunit 50S. Specifically, these antibiotics bind in two well-specific regions to the 23S ribosomal RNA molecule. The macrolide-RNA binding 23S prevents the same RNA from completing protein synthesis, thus inhibiting bacterial growth.

Protease inhibitors. The HIV virus is responsible for the acquired human immunodeficiency virus (better known as AIDS). HIV is a Retrovirus, a particular type of RNA virus (learn more). To be able to replicate, this virus needs to convert its RNA into DNA; such conversion occurs thanks to a particular enzyme, reverse transcriptase. Some anti-HIV agents act by inhibiting, precisely, reverse transcriptase. Among these inhibitors, we mention zidovudine, didanosine, zalcitabine, lamivudine and stavudine. Other antiretroviral agents act by inhibiting HIV protease, a key enzyme for viral growth.

Ritonavir and indinavir are protease inhibitors. Protease inhibitors can be administered in combination with reverse transcriptase inhibitors to try to improve the effectiveness of the therapy. Consult your doctor who prescribes your protease inhibitor before taking Viagra.

Drugs that can mess with your erectile function

Many medicines may have an impact on the erectile function of man.

This is the case for the following medicines:

Antidepressants
Antihypertensive drugs
Lipid-lowering agents
Anti-epileptics
Anti-ulcer drugs
Antiarrhythmics, digitalis
Antiandrogens
Neuroleptics also often cause sexual problems.
Alphablockers; finasteride
Antiretroviral drugs prescribed for the AIDS virus
Cancer chemotherapy

However, it is important to remember that these medicines are prescribed for particular medical conditions. Before stopping any treatment, it is essential to seek the advice of your attending physician.

Antidepressants

Many antidepressants do not have side effects that have an impact on libido and especially on erection in men. This is particularly the case of selective serotonin reuptake inhibitors. These drugs increase the level of serotonin, a neurotransmitter present in the brain. In men treated with these molecules for depression or anxiety, the best being begotten will have a direct impact: the return of desire. But it is not uncommon that because of this treatment, the erection is insufficient or difficult to obtain. The risk is that the patient prematurely ceases treatment, resulting in a return of depression.

This is why you should not hesitate to talk to your doctor about these side effects, even if they seem difficult to tackle. Other molecules can be proposed, without affecting the erection, but especially allowing the patient to cure his depressive episode.

My Canadian Pharmacy recommends for read: Depression in Men: Choosing the Right Treatment

Medications for high blood pressure

Hypertension, poorly known, especially in the oldest subjects, is a risk factor for infarction, stroke but also erectile dysfunction. The antihypertensive drugs most likely to cause erectile dysfunction are diuretics, beta-blockers and ACE inhibitors. There are, however, other types of antihypertensive agents that do not cause such side effects. Again, in the event of undesirable side effects on sexuality, it should be discussed with the doctor before suspending or stopping treatment.

Medications for cholesterol and diabetes

Statins, treatments used to treat excess cholesterol, are also likely to cause erectile dysfunction. Indeed, these drugs fight effectively against cholesterol but also lead to a decline in testosterone levels. However, this hormone plays an important role in the occurrence of an erection. Nevertheless the excess cholesterol altering the arteries, it can also be responsible for an erectile dysfunction. So do not hesitate to discuss this with your doctor who will prescribe a better treatment if needed.

Anti-epileptics

Medications used to treat epilepsy (diphenylhydantoin, phenobarbital, carbamazepine, valproic acid, etc.) often have troublesome side effects. In particular, they decrease excitation and thus cause erectile dysfunction in humans. Stopping medication because of these troublesome side effects may seem like a good solution, but this will lead to an upsurge in the onset of seizures and may even prove dangerous.

Safety of Viagra intake reinforced by My Canadian Pharmacy

Before starting taking sildenafil, it is recommended that you consult your physician, especially in the presence of cardiovascular disease or other pathologies; in some risk subjects you may need to perform some medical examinations to avoid any possible complications.

The recommended starting dose of sildenafil for the treatment of erectile dysfunction in adults is 50 mg of medication to be taken as needed: the dose should be administered approximately 1 hour before the onset of the sexual act.

Dosage information and how to take Viagra – read in this guide: http://www.mycanadianpharmacygroup.com/generic-viagra

It is recommended not to exceed the amount of a single dose per day. The recommended maintenance dose should be decided based on individual patient response and may vary from 25 to 100 mg, to be taken from 30 minutes to 4 hours before sexual intercourse. It is recommended not to exceed the amount of a daily dose. Use in the treatment of erectile dysfunction in the elderly The recommended dose of sildenafil for the treatment of erectile dysfunction in elderly or geriatric patients is 25 mg / day, to be taken approximately one hour before sexual activity.

Use of sildenafil in patients with liver or kidney problems. The dose recommended for the treatment of erectile dysfunction in patients with impaired renal or hepatic function should not exceed 25 mg of sildenafil per day, to be taken up to one hour before sexual activity. For the treatment of arterial pulmonary hypertension, however, there is no need to adjust the dose of sildenafil to be given.

Important considerations

Before starting treatment with erectile dysfunction with sildenafil you should always keep in mind that the medication does not work in the absence of sexual stimuli; in practice, sildenafil cannot help the patient have an erection if the latter does not have sufficient sexual stimulation.

Sildenafil is also a hypotensive drug, which, when administered with other drugs of similar properties – such as nitrates – may cause an excessive drop in blood pressure; Therefore, antihypertensive patients are advised to pay particular attention to taking sildenafil or to find another remedy for the treatment of erectile dysfunction.

The increase in sildenafil dose beyond the therapeutic doses does not in any way increase the effectiveness or the positive effect on erection. In fact, clinical studies have confirmed that the administration of sildenafil at 200 mg doses only increases the side effects of the drug without causing any variation in effectiveness; The same reasoning applies to doses even higher than sildenafil (single doses up to 800 mg of sildenafil were administered in the study).

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Far-Eastern Urologists Say About Viagra, Levitra And Cialis

Specialists from Chinese Medical research study institute have conducted their own examination of PDE5 inhibitors in order to compare their effectiveness. In therapy of potency disorders, the leading role belongs to tableted medications, such as Cialis, Levitra and Viagra and their multiple generics. Competent selection of required tablets is possible in case of estimation of drug’s mechanism of action and consumer’s requirements. It is important to gain insight into similarity and difference in action of these remedies. Far-eastern urologists conclude about similar characteristics of products, their distinguishing features and the way they should be chosen.

Similar Characteristics

Cialis and Viagra have very much in common. The main reason of their administration is to enhance erection and make sure that sexual intercourse will be flawless. These medicinal products belong to the group of phosphodiesterase type 5 inhibitors. These remedies vasodilate selectively vessels of penile cavernous bodies increasing its blood filling rate, enlarging its size and making it dense.

They both have convenient medicinal tableted from and have a lot of generics, such as:

They do not take action without sexual excitement (without beloved desired women and stimulation).
Tablets must be taken before sexual intercourse.
Tablets get disintegrated by means of enzymes produced by liver; therefore, hepatic disorders are generally contradiction to usage of such tablets due to overdose and side-effects.
These medications are not to be combined with medications which are generally used by patients suffering from coronary heart disease (such as nitrates of short of long-term action). Their combined intake may lead to sudden blood pressure drop till life-dangerous indicators.

These tablets have other counter-indications:

impairment of penis structure;
presence of sharp fluctuations of arterial blood pressure;
co-administration with indinavir and erythromycin (combined intake may cause increased concentration of PDE5 inhibitors in blood from 56 up to 210 per cent) that may be life-dangerous.

Distinguishing Features

Viagra (sildenafil) has a long history of application and s better known by consumers. They are familiar with its safety features accompanying therapy of erectile dysfunction. Its tablets have generics of Indian origin under the name of Delgra, Sildena, Eregra, and many others the price of which is 6-8 times lower than the one for the original Viagra.

As to their composition, they have sildenafil as well but in slightly less dosage. Consumers’ reviews state that the tablets of each generic are quite enough for sufficient result which is practically the same as Viagra’s one in case of one-time intake. Its action starts in 15 minutes after medication’s swallowing, reaches its maximum in an hour and lasts three-four hours. The intake of fatty food will decrease the effect; alcohol is counter-indicative, since there is a possibility of overdose and side-effects (such as intoxication). The latter may include blushing, headache, changing of vision. It is worth mentioning that Levitra doesn’t give such effects.

According to Far-eastern experts, Cialis (tadalafil) pills are quickly absorbed in stomach (in 16 minutes), reach their maximal concentration in 2 hours and preserve ready erection for 36 hours. Cialis may be administered 2 times a week in order to ensure fully-realized sexual intercourse. The comparison of Cialis and Viagra duration of action is 18 to 1. Such unique characteristics of Cialis made this remedy quite popular.

Cialis generics, Tadalel, Tadalox, Tadaga, Erectafil, etc., of Indian producers contain tadalafil and their price is 2-4 times lower than the original’s one. Customers’ testimonials prove that this remedy is tolerated better. Even fatty food and average amount of alcohol do not cause manifestation of its adverse features. The excessive use of alcohol causes side-effects of Cialis and Viagra. Since 2003, application of Cialis increased the possibility of erectile dysfunction.

There is also a possibility to compare the action of such medications as Viagra and Levitra (which appeared on pharmaceutical market quite recently). Viagra and Levitra are similar according to the duration of action, although Levitra is better tolerated, since it has less adverse effects, than Viagra. For that reason, its price is dearer than Viagra’s. But Levitra’s generics (including Zhevitra, Vardena, Lovervitra and others) have quite reasonable price. They can be applied even when there is no confidence in male capacities even with men who do not suffer from erectile dysfunction (in case of anxiety or neurosis in presence of love object).

The choice of erection pills is broad, but which of them is the best for each man is to be decided by a medical specialist. Nevertheless, it is possible to yield to the following advice. The medication should be chosen in accordance with the purposes pursued. If a person wants to get a short-term result – to make potency better for several times, cheap Viagra is generally selected. This is perfect for that objective. If a person wants to spend a lot of time staying sexually active, he should choose Cialis. In case a man has to take drugs continuously, it is better to administer Levitra or Zidena. They have less pronounced side-effects and will be tolerated better than other medications.

What is better: Cialis or Levitra or Viagra, or some of their generics? Each person will make his individual conclusions in accordance with his demands. The collation of the action of the afore-mentioned remedies is only a short guideline among a great variety of medications for erectile dysfunction. The reviews of Eastern therapists are quite interesting. There are no absolutely safe medicinal products, but there is always a possibility to choose those that bring minimal harm to organism along with maximum of useful results.

My Canadian Pharmacy compares some of the drugs: Viagra, Cialis and Kamagra: Their Pros and Cons in Treating Erectile Dysfunction

Final Conclusion

To sum up and decide which medication is better either for newcomer or experienced user, it is important to note that everything depends on man’s age, his desires and preferences. Each remedy is good and approved for one-time intake. It goes without saying that in case you are beyond forty years of age but have a good health state – you may start with Viagra (25mg). In case there are doubts, give preference to Levitra’s minimal doses. If you want to have multiple sexual intercourses for a prolonged period of time, it is better to use Cialis in its minimal dose.

A sound and energetic young man may choose any medication with a bigger dose of active substance in medicines. Representatives of the stronger sex over 55 years of age should select any drug in his sole discretion but first, it is better not to start with lovable Cialis. As practice shows, many physicians prescribe Cialis more frequently for aged men to struggle against sexual issues more efficiently. It is worth mentioning that before the intake of any of these medications, it is important to consult a specialist in order to select the most ideal remedy as per individual preferences.

ED Pills Vs. ED Creams: Breaking Down The Unique Features

Erectile dysfunctions are one of the most widely spread health problems among men of all ages, nationalities, professions and all around the globe. The roots of the problem can be different, these can be some psychological problems and physiological as well. Anyway, the result is always the same, weak erection or its full absence. When the first symptoms occur they may spoil and destruct one’s life. Men start feeling useless, fall into a deep depression and stop living a full life.

Fortunately, the pharmaceutical industry had developed some really powerful tools that help to bring back the power of strong erection. The greatest breakthrough in this research field was the creation of Viagra and its further clones and generics. There are also different testosterone boosters that also guarantee high effectiveness. Some real novelty is special creams that have to be applied on the penis and their manufacturers also guarantee the positive results. Such non-classic treating methods like creams are not accepted by the classic medicine, yet there are thousands of positive feedbacks who have used such creams.

In the following article, we will compare classic ED pills with the creams, find out the main differences and peculiarities.

Classic Viagra: Time Proved Method to Getting Strong Erection

Viagra with its active element Sildenafil was created by the scientists from Pfizer to treat pulmonary arterial hypertension. The first researches showed that it is also extremely effective in treating the symptoms of erectile dysfunctions. Such effect is achieved by the ability of Sildenafil to relax the muscles inside the walls of blood vessels inside the penis so that the blood flow could be improved.

Viagra works only symptomatically, it will not help you to treat the reason of your low erection. Besides, it does not increase the libido; you have to be able to become sexually stimulated by your own. The medicine belongs to the class that has to be taken only by a prescription as it has a long list of side effects that may be caused by wrong dosages and self-treatment.

Viagra is very effective, it guarantees up to 6 hours of strong erection. Millions of men around the globe have felt their second youth with these magic blue pills. The minimum dosage starts from 30mg of Sildenafil that has to be before the sexual act. Any changes can be done only under the doctor’s control. The special attention has to be paid to the old-aged patients as they lie under the higher risk of getting side effects concerning problems with the heart. The drug is strictly prohibited to be taken by the patients under eighteen.

Cialis: Another Powerful Source of Man’s Power

This medicine was created by Eli Lilly company together with YCOS corporation. The main active element is Tadalafil. Cialis has much the same method of working as Viagra. It relaxes the blood vessels inside the penis which helps to achieve a fast and strong erection. Tadalafil is also taken to treat the enlarged prostate.

Before starting taking this medicine, one should always consult a doctor. He will help you to determine most effective and less risky dosage concerning side effects.

The minimum dosage of Cialis starts from 5mg once a day. The active element becomes active for 36 hours. The pills have to be taken with or without food.

Side Effects and Precautions

Side effects of drugs like Viagra, Cialis, and their generics are almost the same. They can be divided into two groups: more and less common, yet more severe side effects. In the first group we can name:

headache;
muscle pain;
diarrhea;
sore throat, etc.

The second group of severe side effects requires an immediate medical help, otherwise, they may lead to fatal aftermaths.

painful erection;
partial or full loss of vision;
convulsions;
hard breathing;
irregular heartbeat;
passing out.

Your doctor should also study your medical history. ED pills are prohibited for those who have problems with the liver or kidneys. Patients with weak hearts are to start from minimal dosages and stay under control. You should always inform your doctor if you have any alcohol or drug addiction.

When one buys ED pills he should always remember about the storing conditions. The pills have to be kept in a dark, dry place with a mild temperature regime. Otherwise, there is a high risk of getting spoiled.

ED Creams as Effective Alternative to Classic Pills

Comparing with pills, ED creams appeared not so long ago, yet they already have a huge army of patients who prefers them instead of the pills. The main advantage of ED creams is the period of the effect coming. It has to be used directly before sexual activity and the effect is achieved in 5 minutes. It is also allowed to use them as a precaution.

The creams usually have a very pleasant smell and play a role of a lubricant. They may improve the length of the penis and prolong the period of a sexual act. The same as pills, creams only give a symptomatic treatment; they do not help to get rid of the reasons of the problem.

How and When to Use

The creams are to be applied locally. The skin has to be washed up and cleaned. Some of them are to be applied only when necessary, before sex, others may require treating courses. Using the ED cream allows having sex with a condom.

The creams are prescribed when:

as a part of the complex treating course;
premature ejaculation;
absence of pleasure during sex;
short sexual act.

Perhaps the only precaution is the intolerance to the active elements. The cases with allergic reactions occur very rarely. If your skin is getting red and you feel itching, call the doctor immediately.

Opposed to the pills, creams do not have such strict rules of storing. It is because they are kept in tubes that protect them from light, moisture and inappropriate temperatures. Get sure that children will not be able to find the cream.

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Levitra and Concomitant Use of Riociguat

When mixing any other medications while on any PDE5 inhibitor, it leads to health complications and adverse body reactions that can’t be treated with regular over-the-counter meds. And though Levitra is the safest of the ED meds, its combination with riociguat has two sides: the first one triggers health issues when doses aren’t adjusted and the second one may treat the blood vessel conditions that are responsible for poor erections.

What Is Riociguat?

The drug belongs to the class of medications under the name soluble guanylate cyclase stimulators. What do they do? These drugs are widely prescribed for their ability to reduce the high blood pressure in lungs. After the administration, a riociguat opens the blood vessels that connect the lungs and heart of a patient.

So, it is clear why this type of drugs is usually prescribed to a patient with CTEPH or Chronic Thromboembolic Pulmonary Hypertension. It is effective in cases when surgery is not an option OR a patient requires additional treatment after a surgery. CTEPH, however, is not the only condition riociguat is for. It also treats those adults with PAH – Pulmonary Arterial Hypertension. In the latter case, the drug can be used either on its own or when combined with other meds. And, frankly speaking, when doses are adjusted, Levitra can become that combination option.

FYI, CTEPH is a very rare condition that is provoked by the occurrence of new blood clots on the lung blood vessels. The clots grow in number and block the flow of blood. When the flow is insufficient, the pressure grows and serious complications are inevitable. As to PAH, it is triggered by the narrowing of the lung’s blood vessels that eventually leads to the increased blood pressure as well. If any of these conditions takes place, a person feels really tired and dizzy.

Can a healthcare professional suggest riociguat for conditions other than the mentioned ones? He surely can. But any use and dose should be discussed with a healthcare professional. Besides, it is forbidden to share the drug with anyone even if his symptoms are very much alike.

Riociguat Contraindications

Riociguat is a potent drug, so its combination with any other medications should be supervised. When taking riociguat and other pills without having dose adjusted, a patient may experience very severe side effects that require immediate medical help. Hospitalization is no exception.

The use of riociguat with other medications that usually influence the (NO-sGC-cGMP) – nitric oxidesoluble guanylate cyclase- cyclic guanosine monophosphate pathway is contraindicated. Why? There are high risks of developing a life-threatening condition of syncope or hypotension. What drugs belong to the group of NO-sGC-cGMP?

They are:

Nitrates that are administered either on a regular basis or intermittently. The effect doesn’t depend on their form (by inhalation, oral or sublingual);
Nitric oxide donors (e.g. amyl nitrite);
PDE-5 inhibitors (phosphodiesterase inhibitors like Vardenafil, Sildenafil, and Tadalafil).

We’d like to pay special attention to the use of Levitra along with riociguat: it leads to adverse reactions that require hospitalization as both medications relax and dilate the blood vessels. A male on impotence treatment pills should have his riociguat dose adjusted and vice versa.

Levitra + Riociguat: Side Effects

The reported side effects are no longer mild as after Levitra administration. They tend to turn into severe complications to be treated by healthcare professionals only.

So, let’s see what should be expected, if doses aren’t adjusted:

Dizziness;
Breathing problems;
Various allergic reactions including swelling of some body parts (usually lips, tongue or face);
Hives, skin rash and/or itching;
Feeling lightheaded/faint;
Chest pain;
Severe headache;
Uncommon diarrhea;
Unusual bruising;
Bleeding;
Nausea and/or vomiting;
Swelling of hands, feet and/or ankles.

It is proven that the very first complications occur during the first hour after administration. Headaches are typical for 18-27% of males, dizziness occurs in around 13-20% of users, dyspepsia is common for 8-16% of patients and nausea becomes the very first symptom in 11-14% of men. Other conditions are less common. For example, hypotension is experienced by 4-8% of men, anemia – by 2-7% of them, constipation – by 1-5% and gastro esophageal reflux disease – by 2-5%.

Some rare complications are abdominal distension and dysphagia, peripheral edema and palpations, epistaxis and nasal congestion.

Read also about side effects of Levitra www.mycanadianpharmacymall.com/generic-levitra-side-effects.html

Levitra + Riociguat: Combination Studies

The medical ground: PHA is a serious condition that progresses pretty quickly. It’s the progress in pulmonary vascular resistance that often leads to RVH – right ventricular hypertrophy, failure and lethal outcome, the condition was the main focus of the study. The aim was to learn the effects of sGC stimulation by PDE-5 inhibitors and riociguat on RV remodeling in PAH.

Methods used: it’s not males but mice that were tested during the study. They were kept under the HOV and NOX conditions (hypoxic and normoxic respectively) during five weeks. Their daily treatment included 100 mg/kg/d of Vardenafil via drinking water and 30 mg/kg/d or riociguat via oral gavage. At the final stage, all the echocardiographic parameters were evaluated. The evaluation was performed with a Vevo-770 high resolution imaging system. The system is equipped with 25-MHz transducer. It measured:

RVID – right ventricular internal diameter;
CO – cardiac output;
TAPSE – tricuspid annular plane systolic excursion;
IVRT – RV isovolumic relaxation time;
MPI – myocardial performance index.

Results of the study: the results showed that both drugs have succeeded in the reduction of RV dilation as well as in the increase of CO. The compounds have improved tricuspid annular plane systolic excursion along with RV isovolumic relaxation time significantly. Besides, the RV MPI (the combination of systolic and diastolic parameters of RV function that is used as the RV global function marker) was improved as well in response to both medications.

It proves that medications like Levitra and riociguat can improve the RV function directly. Though, only mice were tested, some male sufferers are already offered to start combining the adjusted doses. However, there are only several cases of this sort of prescription, which means that no human results are available yet.

My Canadian Pharmacy – mycanadianpharmacymall.com

Viagra Cream With No Side Effects: Is It In The Pipeline?

There is a wide range of creams-erection stimulants. As a rule, they may be referred to remedies of the first aid. They are useful when you have no possibility or have counter-indications to other ED treating medications.

Creams, gels and sprays are divided into two categories:

Medications vasodilating penis cavernous bodies promoting blood flow and considerable erection boost.
Prolongators enhancing duration of erection

Let us examine the first group more thoroughly. Remedies for erectile functioning boost are produced in the form of creams; whereas sprays for this purpose do not exist (they can only prolong erection). They should be applied directly on sexual organ, mainly on balanus. The effect occurs in several minutes and lasts around two-three hours.

Viagra Creams or Tablets: What to Choose?

Notwithstanding the fact that some doctors do not treat creams for ED not well, sometimes they are the better choice in comparison with tablets.

Why then?

The pill gives a shorter effect as opposed to the cream.
If you are planning a romantic dinner with alcoholic beverages, you should bear in mind that medicinal products are not to be combined with ethanol.
Tablets take systemic influence on the whole organism and have a number of adverse effects. Tablets are important when a man has strong erectile disorder, impotency or absence of desire.

In case your erection is low resulting from weariness and other causes not connected with health issues, it is better to opt for creams boosting erectile function. Since creams for ED improvement are applied locally, they do not cause any side-effects on organism. Besides, they may be a perfect lubricant.

It is worth mentioning that in some cases a woman may experience slight itching of burning on sexual organs. This effect occurs very seldom and disappears very fast. In case the burning feeling remains, it is recommended using a preservative. According to medical experts, these creams are quite efficient and qualitative products.

Creams for Potency Boost

Light analgesic effect of these creams does not cause any harm to male organism. These remedies do not have counter-indications excluding hypersensitivity to remedy’s ingredients. The creams take their action right from the moment of application. Moreover, due to the fact that their chemical composition is rather similar, a man may choose the medication for the most reasonable price.

The remedy is applied on penis by covering it on balanus. Sometimes men feel unconfident of successful sexual intercourse. In this case, cream would be very helpful.

When Are Creams Useless?

Erection boosting creams may be useless in case your problem is explained by absence of desire, impotency, etc. In case your erectile issues occurred due to age, weariness, and stresses, they will be of considerable assistance.

Viagra Cream Development

25 years ago, Viagra first appeared on pharmaceutical market and became irreplaceable for men suffering from erectile dysfunction all over the globe. But since Viagra and its analogues are helpful for not everyone, special cream should be useful in such cases.

Viagra and other medications improving blood stream to pelvic organs have helped to dozens of millions of men to take pleasure of sexual life again. But therapy with these medicines for some men become ineffective, others may have counter-indications to their ingredients due to side-effects development. Moreover PDE5 inhibitors are contraindicative to people suffering from severe cardio-vascular diseases. Thus, it is quite possible that this group of patients will acquire a very effective remedy booing potency. In the U.S. pharma companies have started clinical trials of cream improving erection. The cream was elaborated with aim at toning of penis. It contains sildenafil acting in the capacity of active substance (in Viagra as well). The New York researchers packed the remedy in nanoparticles easily penetrating through skin.

Small pilot trial was conducted on 18 rats with genetically induced erectile dysfunction. Eleven of them taking experimental cream experienced improvement of condition, whereas seven rats with empty nanoparticles didn’t have any significant change.

This healing ointment should be rubbed in penis right before planned sexual intercourse. The main advantage of the cream it its local application. After its usage, the amount of penetrated in blood sildenafil is as twenty times as lower than after peroral intake. Danger of side-effects development decreases correspondingly (strong headache, blushing, nausea, etc.). Another benefit of Viagra cream lies in the fact that it doesn’t require doctor’s prescription, since overwhelming majority of ED remedies may be bought only with specialists’ confirmation.

U.S. vs UK Developments

Scientists from British and American pharmacological companies have almost simultaneously realized that ED solution lies in creation of local administration remedy, since it may reduce the occurrence of side-effects considerably. Scientists from various countries have chosen various ways for realization of this purpose. U.S. medical experts have elaborated cream of rubbing in penis containing sildenafil which is a key component of Viagra blue pills.

In the UK a cream for erectile dysfunction therapy under the trade name Vitaros with active substance alprostadil was approved. Alprostadil was used earlier for sexual problems treatment, but in a rather sophisticated form: a man had to inject the remedy in penis by means of syringe before sexual intercourse. This fact limited the administration of alprostadil, since not everyone was ready to fulfill this uneasy operation for experiencing several romantic minutes.

Cream with alprostadil made the whole task much easier. It is enough to press out a small amount of cream from tube and cover it in balanus. Cream provides the occurrence of erection within five-thirty minutes. This magic ointment is available only on doctor’s prescription.

Vitaros Description

Alprostadil is a medication of prostaglandin E. It improves microcirculation and peripheral blood circulation, and takes angioprotective action. In case of systemic application is causes relaxation of smooth cell muscles, takes vasodilating action, decreases peripheral vascular resistance, and reduces arterial blood pressure. Moreover, reflectory increase of cardiac output and fatal accident rate are observed. It improves blood rheological properties enhancing elasticity of erythrocytes, and reducing aggregation of thrombocytes and activity of neutrophilic leukocytes. Alprostadil increases blood fibrinolytic potential.

It blocks alpha adrenergic blocking agents in penis tissues, takes soothing action on unstriated muscles of cavernous bodies, promotes increase of blood supply and improvement of microcirculation. Enlargement of cavernous arteries and vessels of trabecular unstriated muscles of cavernous bodies leads to fast increase of blood stream and dilation of lacunas in cavernous bodies. Venous reflux through vessels located under albugineous coat is limited resulting in stimulation of erection development. The onset time is within 5-30 minutes; the effect lasts one-three hours.

Vitaros is indicative in case of neurogenic, vascular, psychogenic or mixed-etiology erection.

It’s benefits are as follows:

Minimum quantity of adverse effects.
It is user-friendly and pretty easy-to-apply. Just moisten and rub it in penis and feel the result within a couple of seconds.
High-rate action makes possible to have perfect erection within 5-30 minutes.
You may avoid side-effects due to its local application. Tablets may result in side-effects (for 1 individual out of 3). Thus, tablets are contraindicative to men suffering from cardiac angina or other cardio-vascular pathologic conditions.

Storage Requirements

Keep out of reach of animals and children. Do not store Vitaros in freezer. If the packages are unopened, you may keep them in the fridge at 4-8°C. Store the packages out of the fridge below 25°C not longer than three days before coitus. Apply Vitaros cream right after opening. Dispose of the remaining cream. Do not use it upon expiration date indicated on the package.

Safety Note

This cream may also be dangerous in the following cases:

Underlying risk for intolerability to alprostadil;
Possible ineffectiveness for ED treatment. Generally this is the case of the patients with severe development of impotency. For those who had beneficial effects from Vitaros intake reported an initial stage of ED. At the same time patients suffering from advanced stage of this disease will unlikely feel the effect of this remedy.

Vitaros Counter-Indications

The list of Vitaros contraindications runs as follows:

Age under 18 years;
Hypersensitivity to remedy’s ingredients;
Affects ability to drive a car or operate machinery;
Pregnancy, lactation.

The Types of Women’s Sexual Health Pills Offered at Canadian Pharmacy

Women’s sexual health is very important for a successful modern woman. However, age-related changes, traumas, and hormonal disorders have a negative impact not only on the overall health of a woman but also on personal relationships because they lead to low sex drive. All of this negatively affects a woman’s psychological health and can lead to low self-esteem and even the occurrence of depression.

Female sex drive can be characterized as a passion or excitement experienced during sexual intercourse. Sex drive can be compared to male potency because these concepts are identical. Both men and women have problems with a decreased sexual activity. According to studies, low sex drive problems occur in 33% of women all over the world. Today, there are many special drugs that help increase libido, and you can find most of them at the Canadian pharmacy.

Reasons of Low Sex Drive in Women

Every woman is individual and has her own threshold of sensitivity, as well as the intensity of sexual arousal, and attraction to a man. Often, the intensity of a sexual desire depends on the hormones in the body of a woman. However, caresses, compliments from men, and romantic atmosphere also help increase sexual desire in women.

There are physiological and psychological reasons of low sex drive.

A woman may not have an orgasm during sexual intercourse for several reasons that include:

Fatigue, stress, and bad mood
Diseases of the female sexual organs, including inflammatory processes
Inflammatory diseases of the genitals
Diabetes, heart diseases, ischemic disease, and pneumonia
A violation of the hormonal background, a decrease in testosterone, or an increase in prolactin
Intake of various drugs, such as birth control or hormonal pills
Menopause, when estrogen is produced in small quantities
Bad relationship with a partner
Emotional distress
Experience of a sexual abuse

All these factors can be the reason of low sex drive and non-receipt of satisfaction from sexual intercourse, which in the future leads not only to frustration in the relationship with a partner but also to emotional trauma. In this case, special drugs designed to increase libido in women can come to the rescue.

Of course, if the reasons for low sex drive are diseases of the female sexual organs, then first you need to eliminate them. Also, before taking drugs to increase libido, you need to consult your doctor.

Drugs That Increase Women’s Low Sex Drive

Pink Female Viagra

The active ingredient of Pink Female Viagra is sildenafil. The drug is very effective in increasing sex drive in women. It helps cope with severe sexual disorders. It is indispensable after taking contraceptives, which negatively affect a female libido.

Pink Female Viagra expands blood vessels in the genital organs enhancing the blood flow. A woman becomes more sexually active and sensitive.

The drug begins to act within an hour after its intake. The drug’s effect lasts for up to 6 hours. After 4 hours, the concentration of the drug’s active ingredient in the blood drops by half.

One pill per day contributes to the following:

Increase in vaginal lubrication
Increase in sexual desire
Clitoral erection
Increase in blood flow to the labia
Increase in the number of orgasms up to 5 times

After taking the drug, headaches and nasal congestion are possible. It is recommended to start with the minimum dosage.

Female Cialis

Female Cialis is a generic drug recommended for women who want to enhance their sexual satisfaction. The medication is applied to restore a natural sexual function in women.

The active ingredient in Female Cialis is tadalafil (10 mg). It is an inhibitor of phosphodiesterase 5 (PDE5), which is used to treat sexual dysfunction. The inhibitor blocks PDE5 and causes relaxation of blood vessels and smooth muscles increasing the blood flow to the genital organs. This action gives a chance to a woman with sexual dysfunction to experience a normal sexual intercourse.

Advantages of Female Cialis:

Promotes emancipation and relaxation
Increases the chances of having an orgasm
Eliminates the disappointment of sexual life
Increases women’s sensitivity to stimulation of the genitals

After taking one pill, the blood flow to the genitals increases. Each caress arouses more emotions and feelings. The walls of the vagina become more sensitive and the production of vaginal lubrication increases during sexual intercourse. All this allows a woman to get a maximum of pleasure and feelings from sex. Note that the drug begins its action only if there is a sexual attraction or arousal to a partner.

Possible Side Effects of Female Cialis

In the course of the study with the use of Cialis in women, minor contradictions were identified.

In some cases, the following side effects of the drug have been observed:

A headache and indigestion (in 11% and 7% of cases, respectively)
Myalgia
Local back pain
Nasal congestion
Redness of the face

In very rare cases women might experience edema of the eyelids, dizziness, pain in the eyes, and conjunctival hyperemia. With prolonged use of the drug, side effects were decreased or gone completely.

How to Use Female Cialis?

The drug should be taken 30–45 minutes before sexual intercourse. The action of the drug gradually decreases within 24–36 hours after the intake.

Sure Romance

Sure Romance is a 100% natural drug that has a fast, long-lasting, and absolutely safe effect on women of any age. It increases the wetness of the vagina, sexual desire, and greatly enhances the sensations during sexual intercourse and orgasm.

The effects of the drug include:

Increase in sex drive
Improvement in the quality of intimate relationships
Reduction in the recovery time after orgasm and preparation for the next sexual intercourse
Possibility to experience multiple orgasms
Increase in satisfaction from sexual intercourse

The drug contains dimethylglycine (DMG), a natural enhancer of sexuality. It stimulates the production of substances that act on the nerve receptors, directing the signal to the brain to increase sexual desire and pleasure.

Contraindications of Sure Romance

Sure Romance is 100% natural, efficient, and safe. No side effects were observed during the time of taking the drug. No contraindications were found. It should be noted that the effect of the drug dramatically increases sexual activity, so women suffering from severe forms of cardiovascular diseases should consult a doctor before taking Sure Romance. In case of painful or unusual sensations, stop taking the drug and see a doctor.

How to Take Sure Romance?

Patients should take 2 capsules of the drug with a full glass of water. A daily reception will provide a readiness for sexual intercourse, restore sexual dysfunction, and increase sexual activity. It is not recommended to exceed the prescribed daily dosage. In case of overdose and the appearance of unpleasant sensations, you should consult a doctor.

It is hard to say unequivocally which of the drugs can overnight increase sex drive in women. Each of them acts differently in each individual case, depending on the age, general health, and individual characteristics of the woman’s body. Therefore, before choosing a drug to enhance and strengthen your sex drive, you should always consult a doctor. Only doctors will be able to give you competent advice and prescribe the drug that will benefit you the most.

Women`s Sexual Pills at Canadian Pharmacy Online – www.mycanadianpharmacymall.com

Why Two Brand Name Erectile Dysfunction Drugs Have Different Prices

In 2016, CVS Health is going to drop coverage of Viagra, the famous little blue pill that caused the rise a multi-billion dollar industry of drugs for erectile dysfunction. This seems to be creating a window for one of the most curious paradoxes of drug pricing ever.

The thing is that CVS is now replacing Viagra with Cialis, which is another brand name drug with a pretty similar effect — and has made a claim that these changes will result in savings on expenditures. However, this isn’t a typical case of a cheaper generic type drug unseating a more expensive brand name product. Both Viagra (by Brand Company), and Cialis (by Eli Lilly and Co.) still have their patents active.

Why does a price difference make CVS drop Viagra?

The Tufts Center for the Study of Drug Development representative and director, Kenneth Kaitin, says that the problem in providing a clear answer is that it requires an invitation to the shady and mysterious world of drug prices. To explain why exactly a certain medicine costs what it costs, he said, it requires an answer more complex than anyone in the general public would appreciate.

“I don’t have a clue, and for that matter people working in the companies quite often don’t have a clue about pricing strategies either,” Kaitin said. The reason is that the companies that cover medicine for patients — pharmacy benefit managers like CVS/Caremark — don’t buy drugs at list price. They don’t even check on every individual drug price, but just buy drugs in bundles.

Maybe, for instance, a drug company gives a better discount if a pharmacy not only buys their erectile dysfunction medicine, but also a set of their cancer drugs and cardiovascular treatments. That shapes a decision to drop one particular drug from the list of medicines covered by a certain pharmacy benefit company. Such changes are hard to dissect. It might have been due to the price of that particular drug, or it might have been about a discount applied to a bundle of drugs.

The Mysterious World Of Drug Prices

Kaitin notes that all the negotiations between drug companies and pharmacy benefit companies are always very secretive, so he can only guess, but generally, companies such as CVS try to get the best deal for their price from the drug companies. One more thing that might be causing this, he says, is that Cialis is also an approved treatment for a disease called benign prostatic hyperplasia that causes urinary problems.

“We do not disclose specific details of our discussions with our payers,” a spokesman for Eli Lilly said in the e-mail. A spokesman for Brand Company said, “Viagra is still available for millions of patients on the market, including many people whose pharmacy benefits are managed by Caremark.”

CVS wouldn’t talk much about the reason why it is substituting Cialis for Viagra, which is just one of more than two dozen other drugs it’s dropping in 2016.

Reassuring Instead of Clarifying

“For those drugs that got removed, equal products with lower prices remain available on the list,” CVS spokeswoman Christine Cramer says in the e-mail. “Since we have introduced our leading and rigorous approach to the drug-list management in 2012, we have provided sufficient savings for our sponsors.”

Moreover, it’s surprisingly difficult to determine the actual price of a drug because it often depends on who is buying and how well the negotiations went. IMS Health, as a vendor of prescription data, is tracking the total revenue of drugs sales. However, even with that much attention to detail, a spokesman noted that you can’t really tell the average price of a certain brand name drug because the data does not track the manufacturer’s coupons, rebates, and other discounts.

Is This Done On Purpose?

If you take a look at the total revenue for one prescription of these drugs, they’re not very different. IMS Health reports that Cialis made $1.4 billion in revenue in 2014 with 7.5 million prescriptions, and Viagra made $1.3 billion with 7.2 million prescriptions. That actually means that Cialis is a bit more expensive per prescription.

If anything, Kaitin points out, the lack of clarity about drug prices marks a problem in the United States health care system, where physicians have to keep track of which pharmacy plans cover which drugs — an ever-changing list for every company.

“I think that most people have no idea how these processes work and we’ve had such a harsh discussion in the U.S. about rationing it and us not wanting to have a European system, that is restricting people from accessing new and important drugs,” Kaitin says. “Actually, that is what we’re doing: drug lists are a way of not letting people gain access to new important drugs.”

Do Blood Pressure Meds Affect Erections? My Canadian Pharmacy Answers

Research by My Canadian Pharmacy Team - www.mycanadianpharmacymall.com

High blood pressure and sex

Hypertension is one of the main reasons for the deterioration of an erection. The problem is that the potency is affected directly by the increased pressure increased and by the drugs designed to reduce high blood pressure. Only modern drugs for treating high blood pressure can cope with this problem.

Fortunately, in recent years there are encouraging prospects for those men with hypertension. Pharmacology managed to create a number of drugs to treat high blood pressure that does not cause erectile dysfunction, even with long-term administration.

Intimate human health is a fundamental right and an essential aspect of normal human life and its quality. Sex life not only affects the feeling of happiness and self-esteem of man, but it also affects life expectancy, the risk of death and the possibility of developing cardiovascular diseases. As for the men, a few studies have convincingly shown that the lower sexual activity causes the higher the probability of death.

High blood pressure and impotence

Hypertension is one of the main causes of premature death in the world today. The complications of high blood pressure are different, for example myocardial infarction, coronary heart disease and stroke – these diseases kill more people than AIDS and cancer every year.

High blood pressure is particularly dangerous for men. In addition, the high blood pressure affects men more often than women. Men have another complication of the hypertension – erectile dysfunction or impotence.

Why does high blood pressure cause erectile dysfunction?

Sponge and the cavernous body of the penis providing erection are the part of the circulatory system and vascular disease due to high blood pressure causes problems with blood vessels of the penis.

Thus, quite frequently the cause of elevated pressure becomes excessive muscle tone in vascular walls, the reduction of which leads to a decrease of pressure and increases blood flow.

Violation of blood filling of the penis, of course, leads to erectile dysfunction. The mechanism of preventing the outflow of blood from the penis through the veins breaks down.

Furthermore, in some cases, erectile dysfunction and high blood pressure may be caused by the same reason – for example, disturbance or production of certain hormones or deposition of cholesterol in the vessels.

In short, the statistics irrefutably proves that there are more men suffering from erectile dysfunction among hypertensive patients than among people who do not have high blood pressure.

High pressure treatment and erectile dysfunction

Even if you are not afraid of the consequences of high blood pressure, such as stroke and heart attack, you need to take the pressure treatment for the sake of sexual health.

Moreover, as already mentioned, quite often, erectile dysfunction and high blood pressure are caused be the same reasons.

First of all, it is necessary to give up smoking – it is one of the main reasons that lead to the development of high blood pressure and erectile dysfunction by damaging effect on blood vessels.

Since high blood pressure and erectile dysfunction are often associated with the deposition of cholesterol plaques on the walls of blood vessels, people with high blood pressure should follow a diet with a reduced amount of animal fats.

However, experience shows that in most cases, if lifestyle changes do not help to normalize high blood pressure (to lower it to a value of 140/90 mm. Hg. Art.), it is necessary to take special medicines for the treatment of pressure.

Drugs against high blood pressure and sexual health

Currently there are many drugs for the treatment of high blood pressure. However, many drugs for the treatment of pressure have an unpleasant effect – they cause erectile dysfunction and decrease libido (sex drive).

Unfortunately the reasons for the so-called primary hypertension are still unknown (this kind of disease occurs in people younger than 50 years in 90-95% of cases and it is not connected with the diseases of other organs). That is why there are no radical methods of treatment of this disease. People have to take special meds for the normalization of the blood pressure for the rest of their lives. In most cases it leads to the problems with erection.

In short, there often are two alternatives for those men who are suffering from high blood pressure:

to treat high blood pressure and live a long life, while suffering from erection problems;
not to treat hypertension, still suffering from erectile problems with the high risk of a stroke or heart attack.

Drugs used in cardiology, often contribute to the development of erectile dysfunction. Lowering blood pressure under the influence of pills weakens the blood supply to the genitals. Beta-blockers and thiazide diuretics often cause a weakening of potency. The advantage is that the sexual act is prolonged. The treatment of hypertension with the use of non-selective beta-blockers often leads to sexual disorders. However, most recent clinical studies have confirmed the relationship of use of beta-blockers with the development of the latest generation of impotence.

According to two large-scale studies, ACE inhibitors, angiotensin II receptor blockers, calcium antagonists have no effect on sexual function.

Beta-blockers are a new generation – they do not impair the potency

After the analysis of questionnaires of 65 patients suffering from coronary heart disease it was found that metoprolol (that has been taken for 4 months) has no significant impact on the sexual life of men. Another cardioselective beta-blokator – bisoprolol does not impair erection and even increases the hardness of an erection during the sexual intercourse.

Top 2016 Erectile Dysfunction Drugs That Really Work by My Canadian Pharmacy

Successfully treating erectile dysfunction can be tricky, since the bodies of different people respond to medications in various ways. Sometimes, it is necessary to try multiple ED drugs to find the one that works best. However, they are generally quite expensive, and every failed attempt is likely to become a negative experience that could add to erectile dysfunction issues in the future. To make sure that you don’t waste your time and money on low-quality ED medicines, we have reviewed most options that are available on the pharmaceutical market today and handpicked only the safest and most effective ones to be presented in this article. So, what are the best medications for addressing erectile difficulties that you can buy in 2016?

At the Top of the List: Generic Viagra (Sildenafil)

Viagra is obviously the product that every man can name off the top of his head when asked about ED drugs. Viagra was the pioneer in this domain and even now, almost twenty years later, it is still able to keep up with its competitors. It is known to deliver the desired effect in more than eighty percent of men while keeping side effects to a minimum.

Generic Viagra works as a powerful PDE-5 inhibitor, which means that the medication increases blood flow to the penis, enabling an erection. It was the first medication that used this mechanism to treat erectile dysfunction. Nearly all of Viagra’s competitors rely on the same mechanism to deliver their effect, while the active components in them are mostly different. Viagra is based on sildenafil citrate, a chemical compound that is also used to treat hypertension. Thus, it is recommended that people who have problems with blood pressure consult a doctor before using Viagra, as they often face a higher risk of developing severe side effects (dangerously low blood pressure, a stroke, or a heart attack). These adverse effects are rather uncommon, while the more frequent ones include headaches, dizziness, flushing, diarrhea, and temporary vision changes.

Generic Viagra is still a great medication for addressing erectile dysfunction. It is fast (generally works in less than one hour), safe, and reliable. However, the pharmaceutical industry is always looking for better solutions, so the list of viable Viagra alternatives is rather impressive.

Additional information: The Benefits of Ordering Viagra Online in My Canadian Pharmacy

Generic Cialis and Levitra from Canadian Pharmacy: The Two Best-Known Generic Viagra Competitors

Generic Levitra hit the market in 2002 when Viagra (Sildenafil) was doing just great. It was the first real competitor of the well-known “little blue pill”. Even though Levitra hasn’t managed to overcome the sales figures of Viagra to this day, it is still quite popular among men who have to deal with erectile dysfunction.

The reasons for its popularity are the following:

reduced risk of side effects in most patients
longer effect (on average, about one hour more)
the ability to address premature ejaculation
slightly quicker onset

These advantages are mostly due to a different active component. Levitra is a market name for a chemical called vardenafil hydrochloride, which can be bought not only in the form of pills but also as an orally dissolving jelly (known as Staxyn).

Generic Cialis (Tadalafil) is another ED medication that became available to the general public in 2003, following Viagra and Levitra. Its main component is tadalafil, which is also a PDE-5 inhibitor, but its chemical structure is slightly different from those of sildenafil and vardenafil. Also, unlike its predecessors, Cialis can be taken not only when it is required (prior to intercourse), but also in smaller doses on a daily basis. Some men find that this approach to using the medication suits them better and yields more satisfying results.

The most common side effect of Generic Cialis is nausea. It is also known to cause muscle aches and/or back pain, which can appear 12-24 hours after taking the medication, and normally disappear within 48 hours. Other adverse effects are similar to those of Generic Levitra or Viagra. Cialis is absorbed into the blood flow rather quickly (in 15 to 45 minutes, depending on the metabolism rate). In most patients, having a full or an empty stomach makes no difference.

Generic Cialis and Levitra are effective ED medicines that are worth trying along with Viagra to determine which one works better for you. Using Cialis on a daily basis can help avoid waiting for the pill to deliver its effect, which can be very annoying if you’re caught in the heat of the moment.

Stendra: the Most Recent Officially Approved ED Medication

It might seem that with three big players on the market, there would be no need (and actually no point) in launching another pharmaceutical with similar effect. Apparently, the drug developers didn’t think so when they released Stendra in 2012.

The main advantage of Stendra is its speed. During clinical trials, ED patients who received various dosages of Stendra according to their prescriptions were able to achieve an erection in as little as fifteen minutes. The amount of food consumed before taking Stendra apparently has no influence on its effect, which can last up to six hours, depending on the patient.

Most people who try Stendra (Avanafil) report that it is a highly effective medication that doesn’t cause as many side effects as Viagra, Cialis or Levitra. However, for some patients, it just won’t work, so it is better if you begin by getting a free sample to see if it works for you or not.

Generics at My Canadian Pharmacy: a Safe Option for a Wallet Full of Money

If you’re not sure that you can give up on your favorite ED medication (whether it is Generic Viagra, Levitra, or Cialis), but it is getting harder and harder to refill your prescription without resenting the high prices, consider trying generics. They are virtually identical to their brand name counterparts, except that they don’t have recognizable features, such as the color and shape of the pill, as well as its packaging. The lack of those attributes can be explained by the inability of third-party manufacturers to use them to market the product. This right is reserved for the original developer even when the patent for the medication expires.

Generics come from manufacturers that are barely known to an average consumer, while brand name drugs are produced by pharmaceutical giants which we know from ads and personal experience. Consequently, you are not sponsoring huge marketing campaigns when you buy generic medications. The only downside to them is the possibility of getting a low-quality product because generics are a lot easier to counterfeit than brand name drugs. Thus, you need to make sure that you purchase generics from a reputable seller that won’t risk your health to raise the profits.

One of the most reliable places to buy generic medicines is My Canadian Pharmacy – an online drug store that won’t disappoint you. You’ll be able to order dozens of high-quality generic pharmaceuticals that will be no less safe and effective than their brand name counterparts, yet won’t cost you a pretty penny. Canadian Pharmacy only works with the best suppliers, which are reviewed on a regular basis to make sure that they do not resort to dishonest practices. Try ordering generic Viagra, Cialis, or Levitra from My Canadian Pharmacy www.mycanadianpharmacymall.com to get the best value for your money.

You are likely to find more pharmaceuticals to address ED if you perform a quick search online, but we believe that only the best medications, which are able to pass quality control by the respective authorities and stand the test of time should be featured on this list.